Search Results - andy berglund

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Modified Pentamidine Analogs Used for Treating Myotonic Dystrophy
BackgroundMyotonic dystrophy (DM) is an incurable genetic disorder that affects 1 in 8000 individuals worldwide. The laboratory of Dr. Andrew Berglund at the University of Oregon has discovered that Pentamidine and other related Diamidines can reverse the progression of this debilitating disease. Myotonic dystrophy is characterized by difficulty re...
Published: 3/26/2014   |   Inventor(s): Andy Berglund, Micah Bodner
Keywords(s):  
Category(s): Therapeutics
Use of Pentamidine in Myotonic Dystrophy Models
Myotonic Dystrophy is characterized by 200–2000 CUG repeats in the 3’UTR of the DMPK gene—unaffected individuals have 5–35 CUG repeats. The CUG repeats form a stem-loop and it’s been suggested that this is a gain-of-function mutation wherein the stem loop binds proteins in the cell so that the proteins are unavailable to perform their normal c...
Published: 5/22/2009   |   Inventor(s): Andy Berglund, Bryan Warf, Leslie VanOs, Catherine Matthys
Keywords(s): Chemical, Therapeutics
Category(s): Research Tools