Tunable Phenylacetylene Scaffolds for Ion Binding updated with additional data

Description:

 

This technology encompasses a series of organic compounds for use in rapid detection of ions and small molecules. 

 

These compounds have a previously unknown framework that is modular and pre-organized to bind guests in its cavity. The modular nature of the framework permits easy synthetic variation of the compound structure and several of the regions can be varied to incorporate a specific property, such as solubility, optimization of guest binding, or fluorescence.

 

The core of the organic framework is a highly-conjugated rigid backbone that makes the framework highly fluorescent. The framework also has limited degrees of freedom that pre-organize the cavity for guest binding and provides several locations for chemical diversification which can be used to adjust solubility or tether the receptor to a solid support.

 

These compounds are designed such that binding or releasing ions from the pocket causes changes in fluorescence or optical properties, thereby creating a very sensitive sensor for ion binding or release.

 

In addition, electron withdrawing versus electron donating groups can “activate” the fluorescent response in the presence of suitable guest molecules.  This was demonstrated with acid and bases and can be accomplished with other target analytes as well.

 

These compounds also change color upon exposure to amines. Guest molecules may include cations (such as arsenic, platinum, or radioactive ions), neutral small molecules, or anions (such as perchlorate, chloride, or bromide).

 

For more information see Dr. Haley's web site and Dr. Johnson's web site  

 

Go to the Office of Technology Transfer

Patent Information:
Category(s):
Diagnostics
For Information, Contact:
James Deane
University of Oregon
jdeane@uoregon.edu
Inventors:
Michael Haley
Darren Johnson
Orion Berryman
Charles Johnson
Calden Carroll Stimpson
Keywords: