Nanohoops as new tools in biotechnology

Description:

Groundbreaking Fluorescent Marker Technology Using Nanohoops

Exceptionally bright nanohoop-based fluorescent markers that are water soluble, and stable at a wide range of pH levels.

 

Background

 

Biocompatible fluorescent molecules are essential for observing complex biological events in real time.

 

 

Tech Overview

 

Researchers at the University of Oregon have devised a groundbreaking fluorescent marker technology that gives researchers a new kind of optical tag to use in biotechnology, biomedical sciences and chemical biology research. These exceptionally bright nanohoop-based fluorescent markers are water soluble, stable at a remarkably wide range of pH levels, and are less likely to lose their intensity due to self-quenching. These new markers can easily be modified to seek out specific cell types – for example, cancer cells – and they likely can be engineered to carry a payload.

Nanohoop fluorescent markers’ unique properties mean they could one day be engineered to deliver a therapeutic compound to a specific cell type, then fluoresce when the compound has been delivered.

 

Benefits

 

Nanohoop fluorescent markers’ many exciting potential benefits include:

 

Nanohoops can easily be made in different sizes, each emitting a different fluorescent color. That means nanohoop markers can potentially be used to simultaneously track multiple functions within a living cell. And, you can use the same laser to excite all of the differently-colored tags at once.

Nanohoop markers are not flat like other fluorescent markers, and their ring shapes give them the potential to transport molecules into cells. This means nanohoops can potentially be used as a trackable therapy delivery system.

The light given off by these nanohoops is very bright, making them easier to image than other fluorescent markers.

Nanohoops are easily functionizable, meaning it’s easy to attach them to proteins, DNA or your molecule of choice.

 

Opportunity

 

Nanohoops are derivatives of [n]cycloparaphenylenes. Their unique properties also make them likely candidates for solar, energy, water filtration, electronics and screens-related research. Other research opportunities include:

 

Any application requiring tagging an antibody with a fluorescent molecule

Research involving tracking any disease state with a protein marker, or with multiple biomarkers

Laser and semiconductor research, solar and energy research, molecular electronics, electronics and screens research, including flexible electronics

Using nanohoops as ligands in metal organic frameworks, transition metal complexes, and enzyme-like catalysts

Nanohoops can potentially transport molecules that turn on – or off – when they encounter a specified substance or condition.

Filtration research, because nanohoops are inherently porous Applications in imaging, infrared light and optics research

 

Patents

 

15/187,644 Donor-acceptor nanohoop compounds and methods of making and using the same 15/900,529 HALOGENATED NANOHOOP COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

16/041,676 Nanohoop Compounds for Use in Biotechnology and Methods of Making and Using the same

 

 

Patent Information:
Category(s):
Chemistry
For Information, Contact:
Christine Gramer
Senior Technology Development Associate
University of Oregon
cgramer@uoregon.edu
Inventors:
Ramesh Jasti
Bruce Branchaud
Brittany White
Keywords: