Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity

University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel disease and to prevent septic shock in zebrafish.

The polypeptides developed using this novel protein can be used to explore new therapies for patients suffering from IBD and for treating any inflammation-related condition, including allergies, asthma, rheumatoid arthritis, inflammatory bowel disease, pelvic inflammatory disease, periodontal disease, polymyalgia rheumatica, atherosclerosis, systemic lupus erythematosus, systemic sclerosis, Sjogren's Syndrome, asthma, allergic rhinitis, and skin disorders, necrotizing enterocolitis and atherosclerosis.

These proteins have been reproduced synthetically, and the synthetic versions also demonstrate anti-inflammatory activity.

Applications:

• This is newly-discovered protein may be developed into therapies to combat inflammation-related conditions in humans, fish and potentially other animals.
• Our polypeptides have been shown to treat and inhibit sepsis or septic shock
• These new polypeptides that can be used to potentially develop therapies to treat rheumatoid arthritis, osteoarthritis, inflammatory lung disease, inflammatory bowel disease, Hirschsprung's associated enterocolitis, pelvic inflammatory disease, periodontal disease, polymyalgia rheumatica, atherosclerosis, systemic lupus erythematosus, systemic sclerosis, Sjogren's Syndrome, asthma, allergic rhinitis, psoriasis, irritable bowel syndrome, necrotizing enterocolitis and other inflammation-related conditions and diseases

Opportunities:

This promising new protein:

• Has been shown to alleviate intestinal inflammation in zebrafish which results from a soy-protein based diet. It can potentially be used to treat intestinal inflammation in farmed fish and other captive fish populations
• Can potentially be used to develop other new therapies that can be used to treat diseases and conditions in farmed, aquarium and pond fish
• Can potentially be used to develop new therapies for Inflammatory Bowel Disease
• Can potentially be used to develop new therapies for treating sepsis and septic shock
• Develop new therapies for burns, wound treatment and other trauma therapies
• Can potentially be used to develop new therapies for inflammation-related conditions of all kinds
• Can potentially be used to develop new non-steroidal anti-inflammatory drugs

For more information , see US Patents 10,752,662 and 11,208,445