Monoclonal Antibodies

Description:

The University of Oregon's Monoclonal Antibody Facility, in close collaboration with university researchers, developed novel monoclonal antibodies against a variety of proteins and peptides that are used in studies of molecular structure, subcellular activities, and cellular differentiation. Many of these monoclonal antibodies are now available through MitoSciences, Inc. Others, listed below, are available by direct licensing from the University of Oregon or through our non-exclusive licensed distributors.

 

Hu proteins are RNA binding proteins that are expressed very early in development. The HuD and HuC protein is expressed only in neurons and their protein expression is considered the earliest developmental marker of neurons and neuronal-derived cells. The HuR protein is expressed in all cell types and is believed to play a major role in stabilizing RNAs in response to molecular stress. Deregulation of HuR is associated with many diseases, including cancer. The anti-Hu antibodies available from the UO are specific for:

 

·         HuD

 

·         HuR

 

·         Pan-Hu (recognizes neuronal Hu protein; HuC, HuD, Hel-N1)

 

Dicer is an enzyme that cleaves double-stranded RNA precursors, generating short interfering RNAs (siRNAs) or microRNAs in the cytoplasm. These small RNAs result in gene-silencing of mRNAs complementary to the small RNAs. The silencing of targeted RNAs "knocks-out" the protein encoded by that RNA.  Thus, the use of small RNAs is a popular method by which researchers control the in vitro expression of specific genes.

 

CDC6 is one of the Cell-Division Cycle proteins that regulate cellular replication and division.  CDC6 is a critical protein involved in the regulating the timing of mitosis.

 

COUP-TF interacting protein 1 (also known as CTIP1; Bcl11A) is implicated in hematopoietic cell development and malignancies.

 

COUP-TF interacting protein 2 (also known as CTIP2; Bcl1b) is involved in regulating the outgrowth and pathfinding of corticospinal motor neuron axonal projections to the spinal cord.

 

 

Zebrafish proteins:         Spadetail (also known as: Tbx16; Veg-T) is a transcription factor required for early mesoderm development.

 

                                    Dlx3b is a transcription factor involved in cell fate specification of neural crest-derived cells.

 

                                   

Zebrafish structures:       Please visit the Zebrafish website

 

Go to the Office of Technology Transfer

Patent Information:
Category(s):
Research Tools
For Information, Contact:
James Deane
University of Oregon
jdeane@uoregon.edu
Inventors:
Keywords:
Antibodies
Biological Materials
Research Tools