The
University of Oregon's Monoclonal Antibody Facility, in close collaboration
with university researchers, developed novel monoclonal antibodies against a
variety of proteins and peptides that are used in studies of molecular
structure, subcellular activities, and cellular differentiation. Many of these
monoclonal antibodies are now available through MitoSciences, Inc. Others, listed below,
are available by direct licensing from the
University of Oregon or through our non-exclusive licensed distributors.
Hu
proteins are
RNA binding proteins that are expressed very early in
development. The HuD and HuC protein is expressed only in neurons and their
protein expression is considered the earliest developmental marker of neurons
and neuronal-derived cells. The HuR protein is expressed in all cell types and
is believed to play a major role in stabilizing RNAs in response to molecular
stress. Deregulation of HuR is associated with many diseases, including cancer.
The anti-Hu antibodies available from the UO are specific
for:
·
HuD
·
HuR
·
Pan-Hu (recognizes neuronal Hu protein; HuC, HuD,
Hel-N1)
Dicer is an
enzyme that cleaves double-stranded RNA precursors, generating short interfering RNAs (siRNAs)
or microRNAs in the cytoplasm. These small RNAs result in gene-silencing of
mRNAs complementary to the small RNAs. The silencing of targeted RNAs
"knocks-out" the protein encoded by that RNA. Thus, the
use of small RNAs is a popular method by which researchers control the in vitro
expression of specific genes.
CDC6 is one of
the Cell-Division Cycle proteins that regulate cellular
replication and division. CDC6 is a
critical protein involved in the regulating the timing of
mitosis.
COUP-TF
interacting protein 1 (also known as CTIP1; Bcl11A) is implicated in
hematopoietic cell development and malignancies.
COUP-TF
interacting protein 2 (also known as CTIP2; Bcl1b) is involved in regulating the
outgrowth and pathfinding of corticospinal motor neuron axonal projections to
the spinal cord.
Zebrafish proteins:
Spadetail (also known as: Tbx16; Veg-T) is a transcription factor
required for early mesoderm development.
Dlx3b
is a transcription factor involved in cell fate specification of neural
crest-derived cells.
Zebrafish structures: Please
visit the Zebrafish
website
Go
to the Office of Technology
Transfer