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A Combined Light Sheet Fluorescence and Differential Interference Contrast Microscope
Light Sheet Fluorescence Microscopy (LSFM) enables imaging of specimens such as live animal embryos, multicellular aggregates, and complex biomaterials with high spatial resolutions, large fields of view, and low levels of photodamage and phototoxicity. However, LSFM does not provide information about the non-fluorescent neighborhood of these cells...
Published: 1/20/2015   |   Inventor(s): Raghuveer Parthasarathy, Ryan Baker
Category(s): Imaging, Research Tools
Fish Housing System
BackgroundOne persistent challenge of fish husbandry is how to capture fish that escape from their tanks and prevent them from entering the local sewer system or contaminating the recirculating water supply. Researchers at the University of Oregon developed a novel device that solves this problem. Catching escaped fish upstream in the system reduc...
Published: 3/26/2014   |   Inventor(s): Tim Mason, Thom Montgomery
Category(s): Research Tools
Modification of Pentatricopeptide Repeat Proteins to Bind Defined Target RNA Sequences
BackgroundThe manipulation of plant genomes is being used to modify traits of agronomic relevance and to exploit plants as biofactories for the production of desired products, such as biofuels, bioplastics or pharmaceuticals. Transplastomics, the introduction of transgenes into plastid genomes, has several key advantages over nuclear genomic transf...
Published: 3/26/2014   |   Inventor(s): Alice Barkan, Ian Small, Sota Fujii, Charles Bond, Margarita Rojas, Yee Seng Chong
Category(s): Research Tools
MADM-TG,p53KO,NF1-flox Mice
These mice may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADAM strain (,and to a Cre recombinase expressing strain. A portion of the cells of the mouse undergo directed somatic recombination resulting in a mouse that is a mosaic for homozygous knockout o...
Published: 3/5/2012   |   Inventor(s): Hui Zong, Chong Liu
Keywords(s): Therapeutics - Cancer
Category(s): Medical Devices, Research Tools
easyCBM is a progress-monitoring assessment system that assists teachers, schools and school districts in making curriculum decisions by assessing the degree to which students have mastered the skills and knowledge deemed critical at each grade level. The assessment principles behind the easyCBM system are the result of over 30 years of publi...
Published: 10/22/2010   |   Inventor(s): Gerald Tindal, Aaron Glasgow, Kirt Ulmer, Julie Alonzo
Category(s): Education & Training, Research Tools
Green Fluorescent Protein Indicating Redox Potential
Changes in the redox equilibrium of cells influence a host of cell functions. Redox-sensitive green fluorescent proteins (GFP) allow real time visualization of the oxidation state of a cell. Go to the Office of Technology Transfer
Published: 5/29/2009   |   Inventor(s): James Remington
Category(s): Research Tools
Mutant Fluorescent Proteins
Functional engineered fluorescent proteins with varied fluorescence characteristics that can be easily distinguished from currently existing green and blue fluorescent proteins. Such engineered fluorescent proteins enable the simultaneous measurement of two or more processes within cells and can be used as fluorescence energy donors or acc...
Published: 5/27/2009   |   Inventor(s): Rebekka Wachter, Atsushi Miyawaki, Juan Llopis, Roger Heim, James Remington, Roger Tsien, Andrew Cubitt, Matts Ormo
Keywords(s): Research Tools
Category(s): Research Tools
Use of Pentamidine in Myotonic Dystrophy Models
Myotonic Dystrophy is characterized by 200–2000 CUG repeats in the 3’UTR of the DMPK gene—unaffected individuals have 5–35 CUG repeats. The CUG repeats form a stem-loop and it’s been suggested that this is a gain-of-function mutation wherein the stem loop binds proteins in the cell so that the proteins are unavailable to perform their normal c...
Published: 5/22/2009   |   Inventor(s): Andy Berglund, Bryan Warf, Leslie VanOs, Catherine Matthys
Keywords(s): Chemical, Therapeutics
Category(s): Research Tools
Culture Collection of Microorganisms from Extreme Environments
The Culture Collection of Microorganisms from Extreme Environments (CCMEE) was created in 1999 by the consolidation of the collections of Dr. E. Imre Friedmann of Florida State University and Dr. Richard Castenholz of the University of Oregon. The newly-formed CCMEE contains cultures from all over the world, including Antarctica, Israel, Asia, Afri...
Published: 5/22/2009   |   Inventor(s): Richard Castenholz, Christopher Wingard
Category(s): Research Tools
Monoclonal Antibodies
The University of Oregon's Monoclonal Antibody Facility, in close collaboration with university researchers, developed novel monoclonal antibodies against a variety of proteins and peptides that are used in studies of molecular structure, subcellular activities, and cellular differentiation. Many of these monoclonal antibodies are now availabl...
Published: 2/19/2009   |   Inventor(s):  
Keywords(s): Antibodies, Biological Materials, Research Tools
Category(s): Research Tools