Search Results - diagnostics

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Thionoesters that Release H2S upon Thiol Ligation

University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in a class...

Published: 5/2/2022 | Inventor(s): Michael Pluth, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics

Gamma-ketothiocarbamate molecules that release COS

Published: 5/2/2022 | Inventor(s): Michael Pluth, Yu Zhao

Keywords(s):

Category(s): Chemistry, Diagnostics, Engineering, Medical Devices, Physical Science, Research Tools, Therapeutics

Innovative, highly-efficient strategies to purify proteins of interest, determine their genomic binding sites, and target their activity to desired genomic regions

Title: A Unified Strategy to Simplify and Enhance Studies of Protein Function Protein studies are universal across disciplines in biological sciences. Because of this ubiquity, numerous strategies exist to purify, localize, redirect, deplete, and visualize proteins in all model organisms. However, it can be cumbersome to create required strains to...

Published: 5/2/2022 | Inventor(s): Jeff McKnight

Keywords(s): Science

Category(s): Diagnostics, Research Tools

SpdE, a novel amino acid-sensing diguanylate cyclase

SpdE, a novel amino acid-sensing diguanylate cyclase Tech ID UO-19-33 Animals are colonized by dynamic communities of bacteria, largely acquired by transmission from the external environment and other hosts; however, the traits that promote a microbe’s ability to be host-associated (i.e. to colonize or otherwise exist within a host) are not...

Published: 6/21/2024 | Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson

Keywords(s): Science

Category(s): Diagnostics, Research Tools, Therapeutics

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation

HEADLINE: Novel protein induces pancreatic beta cell proliferation, is ideal for diabetes treatment research Our scientists discovered a novel protein that offers a potential new avenue of research for labs developing drugs to treat diabetes. The newly-discovered BefA (β Cell Expansion Factor A) protein acts to increase total pancreatic...

Published: 10/19/2023 | Inventor(s): Karen Guillemin, Jennifer Hampton

Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish

Category(s): Diagnostics, Therapeutics, Research Tools

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity

HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...

Published: 11/4/2024 | Inventor(s): Karen Guillemin, Annah Rolig

Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish

Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics

Tunable Phenylacetylene Scaffolds for Ion Binding

The Phenylacetylenes are a new class of organic compounds that are able to bind negatively charged molecules. The binding of anions is an important problem in chemistry for multiple reasons. For instance, many anions (such as perchlorate, nitrate, and pertechnetate) are environmental contaminants, and recovery of anions from a feed stream may enhance...

Published: 10/1/2021 | Inventor(s): Michael Haley, Darren Johnson, Orion Berryman, Charles Johnson

Keywords(s):

Category(s): Diagnostics, Chemistry

Tunable Phenylacetylene Scaffolds for Ion Binding updated with additional data

This technology encompasses a series of organic compounds for use in rapid detection of ions and small molecules. These compounds have a previously unknown framework that is modular and pre-organized to bind guests in its cavity. The modular nature of the framework permits easy synthetic variation of the compound structure and several of the...

Published: 10/1/2021 | Inventor(s): Michael Haley, Darren Johnson, Orion Berryman, Charles Johnson, Calden Carroll

Keywords(s):

Category(s): Diagnostics