Search Results - diagnostics

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Malassezia-Secreted Factor with Antibiotic Activity

1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...

Published: 1/8/2026 | Inventor(s): Matthew Barber, Caitlin Kowalski

Keywords(s):

Category(s): Therapeutics, Diagnostics, Research Tools

Anion Sensing with nanoMOF Electrodes

1. Technology Overview The invention introduces a novel method for selective anion sensing using chromium triazolate metal-organic framework (MOF) nanocrystals. These nanocrystals enable the detection of anion identity and concentration through voltammetric sweeping, offering high selectivity, sensitivity, and reusability. The technology leverages...

Published: 1/7/2026 | Inventor(s): Carl Brozek, Jiawei Huang

Keywords(s):

Category(s): Chemistry, Diagnostics, Materials Science, Physical Science, Nanoscience & Microtechnologies

Non-Linear Single-Molecule FRET

1. Technology Overview The invention introduces a novel method for measuring the relative orientation of donor-acceptor (D-A) pairs in fluorescence resonance energy transfer (FRET) microscopy. This method leverages non-linear spectroscopy and phase-tagged photon counting to achieve precise measurements of the relative orientation and distance between...

Published: 12/31/2025 | Inventor(s): Andy Marcus, Claire Albrecht

Keywords(s):

Category(s): Imaging, Diagnostics

Method for Detection for Hydrosulfide Anion (HS-) and Hydrogen Sulfide (H2S)

1. Technology Overview The invention focuses on a new method for detecting hydrosulfide anion (HS⁻) and hydrogen sulfide (H₂S) using reversible, supramolecular binding interactions. This method utilizes non-covalent interactions, specifically hydrogen bonds, to detect HS⁻/H₂S without altering the analyte concentration. The technology is currently...

Published: 1/7/2026 | Inventor(s): Michael Haley, Darren Johnson, Michael Pluth, Ryan Hansen, Matt Hartle, Blakely Tresca

Keywords(s):

Category(s): Chemistry, Materials Science, Physical Science, Imaging, Therapeutics, Research Tools, Diagnostics

Thionoesters that Release H2S upon Thiol Ligation

1. Technology Overview The invention focuses on synthesizing thionoesters that release hydrogen sulfide (H₂S) upon thiol ligation. These small molecules react with L-cysteine and other cysteine derivatives to release H₂S, terminating in the formation of N-benzoyl-L-cysteine. The technology is currently in the development stage, with promising cross-industry...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics

A Unified Strategy to Simplify and Enhance Studies of Protein Function

Protein studies are universal across disciplines in biological sciences. Because of this ubiquity, numerous strategies exist to purify, localize, redirect, deplete, and visualize proteins in all model organisms. However, it can be cumbersome to create required strains to investigate the many different aspects of protein function. Even in yeast, one...

Published: 1/8/2026 | Inventor(s): Jeff McKnight

Keywords(s): Science

Category(s): Diagnostics, Research Tools

SpdE, a Novel Amino Acid-sensing Diguanylate Cyclase

1. Technology Overview The invention introduces SpdE, a novel bacterial protein that senses specific amino acids (valine, proline, and isoleucine) at nanomolar concentrations. This highly sensitive protein offers significant potential for applications in clinical diagnostics, biotechnology, and industrial processes. The technology leverages established...

Published: 1/8/2026 | Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson

Keywords(s): Science

Category(s): Diagnostics, Research Tools, Therapeutics

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation

This invention enables a novel, microbiome-derived approach to diabetes treatment by leveraging a protein from the gut bacterium Aeromonas that increases pancreatic β cell number through enhanced proliferation, differentiation, and survival. By targeting restoration of insulin-producing β cells, the technology addresses a core unmet need in...

Published: 1/6/2026 | Inventor(s): Karen Guillemin, Jennifer Hampton

Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish

Category(s): Diagnostics, Therapeutics, Research Tools