Search Results - therapeutics

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Malassezia-Secreted Factor with Antibiotic Activity

1. Technology Overview The invention introduces a novel antimicrobial activity produced by human-associated fungi, specifically Malassezia sympodialis, for potential development as antibiotics. The secreted factor exhibits bactericidal activity against Staphylococcus aureus and enhances bacterial sensitivity to other antibiotics, making it suitable...

Published: 1/8/2026 | Inventor(s): Matthew Barber, Caitlin Kowalski

Keywords(s):

Category(s): Therapeutics, Diagnostics, Research Tools

Moderate-Affinity Affibodies for Controlled Protein Delivery and Bioactivity

1. Technology Overview The invention introduces a novel method for controlled protein delivery and bioactivity using moderate-affinity affibodies. These 58-amino acid peptides can specifically bind to various proteins, allowing for the controlled release or sequestration of multiple payloads within a single vehicle. The technology leverages the conjugation...

Published: 1/8/2026 | Inventor(s): Marian Hettiaratchi, Henry Hochstatter, Veronica Spaulding, Jonathan Dorogin, Alycia Galindo, Chandler Asnes, Madeline Martin, Justin Svendsen

Keywords(s):

Category(s): Medical Devices, Therapeutics, Materials Science

Anisotropic Poly(ethylene glycol)-Based Hydrogels Synthesized via Two-Stage Polymerization and Mechanical Alignment

1. Technology Overview The invention introduces synthetic poly(ethylene glycol)-based hydrogels with anisotropic polymer network topology, mimicking the structure of musculoskeletal tissues. These hydrogels are synthesized using a two-stage polymerization process, allowing for the application of mechanical force to impart anisotropy. The technology...

Published: 1/2/2026 | Inventor(s): Danielle Benoit, Tayler Hebner

Keywords(s):

Category(s): Chemistry, Therapeutics

Biological H2S / COS Donation by Thiocarbamates

1. Technology Overview The invention focuses on biological hydrogen sulfide (H₂S) and carbonyl sulfide (COS) donation using thiocarbamates. These compounds release COS, which is then converted to H₂S by hydrolysis or metabolism by carbonic anhydrase. The technology is currently in the development stage, with promising cross-industry applications in...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao

Keywords(s):

Category(s): Chemistry, Physical Science, Therapeutics

Method for Detection for Hydrosulfide Anion (HS-) and Hydrogen Sulfide (H2S)

1. Technology Overview The invention focuses on a new method for detecting hydrosulfide anion (HS⁻) and hydrogen sulfide (H₂S) using reversible, supramolecular binding interactions. This method utilizes non-covalent interactions, specifically hydrogen bonds, to detect HS⁻/H₂S without altering the analyte concentration. The technology is currently...

Published: 1/7/2026 | Inventor(s): Michael Haley, Darren Johnson, Michael Pluth, Ryan Hansen, Matt Hartle, Blakely Tresca

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Category(s): Chemistry, Materials Science, Physical Science, Imaging, Therapeutics, Research Tools, Diagnostics

Compounds for Thiol-Triggered COS and/or H2S Release and Methods of Making and Using the Same

1. Technology Overview The invention focuses on thiol-triggered sulfenyl thiocarbonates and sulfenyl thiocarbamates that release carbonyl sulfide (COS) and hydrogen sulfide (H₂S) in the presence of biologically relevant thiols. These compounds offer a concomitant fluorescence response, providing optical indication of COS and H₂S release. The technology...

Published: 1/2/2026 | Inventor(s): Michael Pluth, Yu Zhao, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Engineering, Medical Devices, Physical Science, Therapeutics

Thionoesters that Release H2S upon Thiol Ligation

1. Technology Overview The invention focuses on synthesizing thionoesters that release hydrogen sulfide (H₂S) upon thiol ligation. These small molecules react with L-cysteine and other cysteine derivatives to release H₂S, terminating in the formation of N-benzoyl-L-cysteine. The technology is currently in the development stage, with promising cross-industry...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics

SpdE, a Novel Amino Acid-sensing Diguanylate Cyclase

1. Technology Overview The invention introduces SpdE, a novel bacterial protein that senses specific amino acids (valine, proline, and isoleucine) at nanomolar concentrations. This highly sensitive protein offers significant potential for applications in clinical diagnostics, biotechnology, and industrial processes. The technology leverages established...

Published: 1/8/2026 | Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson

Keywords(s): Science

Category(s): Diagnostics, Research Tools, Therapeutics

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation

This invention enables a novel, microbiome-derived approach to diabetes treatment by leveraging a protein from the gut bacterium Aeromonas that increases pancreatic β cell number through enhanced proliferation, differentiation, and survival. By targeting restoration of insulin-producing β cells, the technology addresses a core unmet need in...

Published: 1/6/2026 | Inventor(s): Karen Guillemin, Jennifer Hampton

Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish

Category(s): Diagnostics, Therapeutics, Research Tools