Search Results - therapeutics

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Biological H2S / COS Donation by Thiocarbamates

University of Oregon researchers are studying reactive sulfur species (RSS). Detection, Delivery, and Quantification of Biological H2S Hydrogen sulfide (H2S), commonly known for its unpleasant rotten-egg smell, is now accepted as an important enzymatically-produced biomolecule that plays important roles in living systems. Joining CO and NO in...

Published: 5/2/2022 | Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao

Keywords(s):

Category(s): Chemistry, Physical Science, Therapeutics

Compounds for Thiol-Triggered COS and/or H2s Release and Methods of Making and Using the Same

Published: 5/2/2022 | Inventor(s): Michael Pluth, Yu Zhao, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Engineering, Medical Devices, Physical Science, Therapeutics

Thionoesters that Release H2S upon Thiol Ligation

Published: 5/2/2022 | Inventor(s): Michael Pluth, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Diagnostics, Medical Devices, Physical Science, Therapeutics

Gamma-ketothiocarbamate molecules that release COS

Published: 5/2/2022 | Inventor(s): Michael Pluth, Yu Zhao

Keywords(s):

Category(s): Chemistry, Diagnostics, Engineering, Medical Devices, Physical Science, Research Tools, Therapeutics

SpdE, a novel amino acid-sensing diguanylate cyclase

SpdE, a novel amino acid-sensing diguanylate cyclase Tech ID UO-19-33 Animals are colonized by dynamic communities of bacteria, largely acquired by transmission from the external environment and other hosts; however, the traits that promote a microbe’s ability to be host-associated (i.e. to colonize or otherwise exist within a host) are not...

Published: 1/25/2023 | Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson

Keywords(s): Science

Category(s): Diagnostics, Research Tools, Therapeutics

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation

HEADLINE: Novel protein induces pancreatic beta cell proliferation, is ideal for diabetes treatment research Our scientists discovered a novel protein that offers a potential new avenue of research for labs developing drugs to treat diabetes. The newly-discovered BefA (β Cell Expansion Factor A) protein acts to increase total pancreatic...

Published: 10/19/2023 | Inventor(s): Karen Guillemin, Jennifer Hampton

Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish

Category(s): Diagnostics, Therapeutics, Research Tools

Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity

HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...

Published: 5/2/2022 | Inventor(s): Karen Guillemin, Annah Rolig

Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish

Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics

Essential amino acid supplementation & geriatric surgery

Total knee arthroplasty (TKA) is used to treat knee pain caused by osteoarthritis. In 2008 over 650,000 TKAs were performed in the US alone. The prevalence of TKA is projected to increase to 3.5 million U.S. patients annually at the current growth rates. Despite success as a treatment for osteoarthritis, TKA leaves patients with persistent muscle...

Published: 6/7/2022 | Inventor(s): Hans Dreyer

Keywords(s):

Category(s): Therapeutics